Publications

2022

Duffet L, Kosar S, Panniello M, Viberti B, Bracey E, Zych AD, Radoux-Mergault A, Zhou X, Dernic J, Ravotto L, Tsai YC, Figueiredo M, Tyagarajan SK, Weber B, Stoeber M, Gogolla N, Schmidt MH, Adamantidis AR, Fellin T, Burdakov D, Patriarchi T. 2022. A genetically encoded sensor for in vivo imaging of orexin neuropeptides. Nat Methods. 2022 Feb;19(2):231-241.

 

2021

Oesch LT, Adamantidis AR. 2021. How REM sleep shapes hypothalamic computations for feeding behaviorTrends Neurosci. 2021 Dec;44(12):990-1003. 

Oesch LT, Adamantidis AR. 2021. Sleep and Metabolism: Implication of Lateral Hypothalamic NeuronsFront Neurol Neurosci. 2021;45:75-90.

Gazea M, Furdan S, Sere P, Oesch L, Molnár B, Di Giovanni G, Fenno LE, Ramakrishnan C, Mattis J, Deisseroth K, Dymecki SM, Adamantidis AR, Lőrincz ML. 2021. Reciprocal Lateral Hypothalamic and Raphe GABAergic Projections Promote WakefulnessJ Neurosci. 2021 Jun 2;41(22):4840-4849.

 

2020

Adamantidis, A.R., Schmidt, M.H., Carter, M.E., Burdakov, D., Peyron, C., Scammel, T.E. 2020. A circuit perspective on narcolepsy. Sleep. 2020 May 12;43(5):zsz296.

Bandarabadi, M., Herrera, C.G., Gent, T.C., Bassetti, C., Schindler, K., Adamantidis, A.R. 2020. A role for spindles in the onset of rapid eye movement sleep. Nat Commun. 2020 Oct 16;11(1):5247.

Battagello, D. S.,Lorenzon, A. R., Diniz, G. B.,Motta-Teixeira, L. C.,Klein, M. O.,Ferreira, J. G. P., Arias, C. M., Adamantidis, A., Sita, L. V., Cipolla-Neto, J., Bevilacqua, Emaf, Sawchenko, P. E., Bittencourt, J. C.2020. The rat mamary gland as a novel site of expression of melanin-concentrating hormone receptor 1mRNA and its protein ImmunorectivityFront Endocrinol. 2020 Jul 31;11:463.

 Cisse, Y., Ishibashi, M., Jost, J., Mainville, L., Adamantidis, A., Leonard, C.S., Jones, B.E. 2020. Discharge and role of GABA ponukogitomesencephalic neurons in cortical activity and sleep-wake states examined by optogenetics and juxtacellular recordings in mice. J. Neurosci. 2020 Jul 29;40(31):5970-5989.

Collins, B., Pierre-Ferrer, S., Muheim, C., Lukacsovich, D., Cai, Y., Spinnler, A., Herrera, C. G., Wen, S., Winterer, J., Belle, M. D. C., Piggins, H. D., Hastings, M., Loudon, A., Yan, J., Foldy, C., Adamantidis, A., Brown, S. A. 2020. Circadian VIPergic Neurons of the suprachiasmatic Nuclei Sculpt the sleep-wake cycleNeuron. 2020 Nov 11;108(3):486-499.e5

 Diniz, G. B., Battagello, D. S., Klein, M. O., Bono, B. S. M., Ferreira, J. G. P., Motta-Teixeira, L. C., Duarte, J. C. G., Presse, F., Nahon, J. L., Adamantidis, A., Chee, M. J., Sita, L. V., Bittencourt, J. C. 2020. Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent mannerJ Neurosci Res. 2020 Oct;98(10):2045-2071.

 Facchin, L., Schone, C., Mensen, A., Bandarabadi, M., Pilotto, F., Saxena, S., Libourel, P. A., Bassetti, C. L. A., Adamantidis, A. R. 2020. Slow Waves Promote Sleep-Dependent Plasticity and Functional Recovery after StrokeJ Neurosci. 2020 Nov 4;40(45):8637-8651.

Hubbard, J., Gent, T. C., Hoekstra, M. M. B., Emmenegger, Y., Mongrain, V., Landolt, H. P., Adamantidis, A. R., Franken, P. 2020. Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep. Nat Commun. 2020 Jun 19;11(1):3130.

 Karnani, M. M., Schone, C., Bracey, E. F., Gonzalez, J. A., Viskaitis, P., Li, H. T., Adamantidis, A., Burdakov, D. 2020. Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiationProg Neurobiol. 2020 Apr;187:101771.

 Oesch, L. T., Gazea, M., Gent, T. C., Bandarabadi, M., Gutierrez Herrera, C., Adamantidis, A. R. 2020. REM sleep stabilizes hypothalamic representation of feeding behaviorProc Natl Acad Sci USA. 2020 Aug 11;117(32):19590-19598.

Pace, M., Colombi, I., Falappa, M., Freschi, A., Bandarabadi, M., Armirotti, A., Encarnacion, B. M., Adamantidis, A. R., Amici, R., Cerri, M., Chiappalone, M., Tucci, V. 2020. Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader-Willi syndrome. Hum Mol Genet. 2020 Jul 29;29(12):2051-2064.

 

2019

Adamantidis, A. R., Gutierrez Herrera, C., & Gent, T. C. 2019. Oscillating circuitries in the sleeping brainNat Rev Neurosci. 2019 Dec;20(12):746-762.

Bandarabadi, M., Boyce, R., Gutierrez Herrera, C., Bassetti, C., Williams, S., Schindler, K., & Adamantidis, A. 2019. Dynamic modulation of theta-gamma coupling during REM sleepSleep. 2019 Dec 24;42(12):zsz182.

Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., Khatami, R., Koning, F., Kornum, B. R., Lammers, G. J., Liblau, R. S., Luppi, P. H., Mayer, G., Pollmacher, T., Sakurai, T., Sallusto, F., Scammell, T. E., Tafti, M., & Dauvilliers, Y. 2019. Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatmentNat Rev Neurol, 15(9): 519-539.

Komagata, N., Latifi, B., Rusterholz, T., Bassetti, C. L. A., Adamantidis, A., & Schmidt, M. H. 2019. Dynamic REM Sleep Modulation by Ambient Temperature and the Critical Role of the Melanin-Concentrating Hormone SystemCurr Biol. 2019 Jun 17;29(12):1976-1987.e4.

Mensen, A., Pigorini, A., Facchin, L., Schone, C., D'Ambrosio, S., Jendoubi, J., Jaramillo, V., Chiffi, K., Eberhard-Moscicka, A. K., Sarasso, S., Adamantidis, A., Muri, R. M., Huber, R., Massimini, M., & Bassetti, C. 2019a. Corrigendum to: "Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches" [Journal of Neuroscience Methods Volume 313, 1 February 2019, Pages 37-43]. J Neurosci Methods, 321: 79.

Mensen, A., Pigorini, A., Facchin, L., Schone, C., D'Ambrosio, S., Jendoubi, J., Jaramillo, V., Chiffi, K., Eberhard-Moscicka, A. K., Sarasso, S., Adamantidis, A., Muri, R. M., Huber, R., Massimini, M., & Bassetti, C. 2019b. Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approachesJ Neurosci Methods, 313: 37-43.

Miladinovic, D., Muheim, C., Bauer, S., Spinnler, A., Noain, D., Bandarabadi, M., Gallusser, B., Krummenacher, G., Baumann, C., Adamantidis, A., Brown, S. A., & Buhmann, J. M. 2019. SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and speciesPLoS Comput Biol, 15(4): e1006968.

Muller Herde, A., Mihov, Y., Kramer, S. D., Mu, L., Adamantidis, A., Ametamey, S. M., & Hasler, G. 2019. Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats. Neurotox Res, 36(4): 806-816.

 

2018

Adamantidis A.; Lüthi a. (2018). Optogenetic dissection of Sleep-Wake States In Vitro and In VivoHandbook of experimental pharmacology, 2019;253:125-151. Epub. Springer Link

 

2017

Boyce, Richard; Williams, Sylvain; Adamantidis, A. (2017). REM sleep and memoryCurrent opinion in neurobiology, 44, S. 167-177. Elsevier

Ferreira, Jozelia Gomes Pacheco; Bittencourt, Jackson Cioni; Adamantidis, A. (2017). Melanin-concentrating hormone and sleepCurrent opinion in neurobiology, 44, S. 152-158. Elsevier

Lörincz, Magor L; Adamantidis, A. (2017). Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogeneticsProgress in neurobiology, 151, S.237-253. Elsevier

Boyce, Richard; Adamantidis, A. (2017). REM Sleep on It! Neuropsychopharmacology, 42(1), S. 375. Nature Publishing Group

Gutierrez Herrera, Carolina; Ponomarenko, Alexey; Korotkova, Tatiana; Burdakov, Denis; Adamantidis, A. (2017). Sleep & Metabolism: the multitasking ability of lateral hypothalamic inhibitory circuitriesFrontiers in neuroendocrinology, 44, S. 27-34. Elsevier

Pace, Marta; Adamantidis, A.; Facchin, Laura; Bassetti, Claudio (2017). Role of REM Sleep, Melanin Concentrating Hormone and Orexin/Hypocretin Systems in the Sleep Deprivation Pre-IschemiaPLoS ONE, 12(1), E0168430. Public Library of Science

Gent, Thomas Clifford; Adamantidis, A. (2017). Anaesthesia and sleepClinical and translational neuroscience, 1(1), 2514183X1772628. Sage Publications.

 

2016

Sclafani, Anthony, Adamantidis, A.; Ackroff, Karen (2016). MCH receptor deletion does not impair glucose-conditioned flavor preferences in micePhysiology & behavior, 163, S. 239-244. Elsevier

Kassiri, Hossein; Chemparathy, Aditi; Salam, M Tariqus; Boyce, Richard; Adamantidis A.; Genov, Roman (2016). Electronic Sleep Stage Classifiers: A Survey and VLSI Design MethodologyIEEE transactions on biomedical circuits and systems, 11(1), S. 1-12. Institute of Electrical and Electronics Engineers IEEE

Boyce, Richard; Glasgow, Stephen D; Williams, Sylvain; Adamantidis, A. (2016). Causal evidence for the role of REM sleep theta rhythm in contextual meomory consolidationScience, 352(6287), S. 812-816. American Associaton for the Advancement of Science

Gutierrez Herrera, Carolina; Cadvieco, Marta Carus; Jego, Sonia; Ponomarenko, Alexey; Korotkova, Tatiana; Adamantidis, A. (2016) Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousnessNature neuroscience, 19(2), S. 290-298. Nature America

González, J Antonio; Iordanidou, Panagiota; Strom, Molly; Adamantidis, A.; Burdakov, Denis (2016). Awake dynamics and brain-wide direct inputs of hypthalamic MCH and orexin networksNature communications, 7(11395), S. 11395. Nature Publishing Group

 

2015

Adamantidis A.; Arber, Silvia; Bains, Jaideep S; Bamberg, Ernst; Bonci, Antonello; Buzsáki, György; Cardin, Jessica A; Costa, Rui M; Dan, Yang; Goda, Yukiko; Graybiel, Ann M; Häusser, Michael; Hegemann, Peter; Huguenard, John R; Insel, Thomas R; Janak, Patricia H; Johnston, Daniel; Josselyn, Sheena A;  Koch, Christof; Kreitzer, Anatol C; ... (2015). Optogenetics: 10 years after ChR2 in neurons - views from the communityNature neuroscience, 18(9), S.1202-1212. Nature America

Gutierrez Herrera, Carolina; Adamantidis, A. (2015). An integrated microprobe for the brainNature biotechnology, 33(3), S. 259-260. Nature America

Colby-Milley, Jessica; Cavanagh, Chelsea; Jego, Sonia; Breitner, John C S; Quirion, Rémi; Adamantidis, A. (2015). Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological StagesPLoS ONE, 10(6), e0130177. Public Library of Science

Bassetti, Claudio; Ferini-Strambi, L.; Brown, S.; Adamantidis, A.; Benedetti, F.; Bruni, O.; Cajochen, C; Dolenc-Groselj, L.; Ferri, R.; Gais, S.; Huber, R.; Khatami, Ramin; Lammers, G.J.; Luppi, P. H.; Manconi, M.; Nissen, C.; Nobili, L.; Peugneux, P.; Pollmächter, T.; Randerath, W.; ... (2015). Neurology and psychiatry: waking up to opportunities of sleep.: State of the art and clinical/research priorities for the next decadeEuropean journal of neurology, 22(10), S. 1337-1354. Blackwell Science

Adamantidis, A. (2015). Modern neurosciences: with or without optogenetics? médecine / sciences, 31(3), S. 231-232 EDP Sciences

Adamantidis, A. (2015). Sleep: the sound of a local alarm clockCurrent Biology, 25(1), R49-R51. Cell Press

 

2014

Adamantidis A., Zhang, Feng; de Lecea, Luis; Deisseroth, Karl (2014). Optogenetics: opsins and optical interfaces in neuroscience. Cold Spring Harbor protocols, 2014(8), S. 815-822. Cold Spring Harbor Laboratory

Adamantidis A., Zhang, Feng; de Lecea, Luis; Deisseroth, Karl (2014). Establishing a fiber-optic-based optical neural interfaceCold Spring Harbor protocols, 2014(8), S. 839-844. Cold Spring Harbor Laboratory

Schöne C, Apergis-Schoute J, SakuraiT, Adamantidis A., Burdakov D. Cotransmission of orexin and glutamate enables parallel, non-redundant outputs from histamine neurons. Cell Reports. 2014 In Press.

Luppi, PH., Adamantidis A.,  Fort P. A The neurophysiology and neurobiology of sleep ESRS 40th Anniversary book, In press.

Adamantidis A., Carter, M.E. and de Lecea, L. Optogenetic control of arousal neurons.Shaw, P., Tafti, M. & Thorpy, M. The Genetic Basis of Sleep and Sleep Disorders. Cambridge University Press, In Press

 

2013

Conductier G, Martin AO, Risold PY, Jego S, Lavoie R, Lafont C, Mollard P, Adamantidis A., Nahon JL. Control of ventricular ciliary beating by the melanin concentrating hormone-expressing neurons of the lateral hypothalamus: a functional imaging surveyFront Endocrinol. 2013 Nov 25;4:182

Jego S, Glasgow SD, Herrera CG, Ekstrand M, Reed SJ, Boyce R, Friedman J, Burdakov D, Adamantidis A.. Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamusNat Neurosci. 2013 Nov;16(11):1637-43.

Zhang Z, Cordeiro Matos S, Jego S, Adamantidis A., Séguéla P. Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptorsPLoS One. 2013 Jun 13;8(6):e66122.

Conductier G, Brau F, Viola A, Langlet F, Ramkumar N, Dehouck B, Lemaire T, Chapot R, Lucas L, Rovère C, Maitre P, Hosseiny S, Petit-Paitel A, Adamantidis A., Lakaye B, Risold PY, Prévot V, Meste O, Nahon JL, Guyon A. Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volumeNat Neurosci. 2013 Jul;16(7):845-7.

Jego S, Adamantidis A. MCH neurons: vigilant workers in the nightSleep. 2013 Dec 1;36(12):1783-6.

Carter ME, de Lecea L, Adamantidis A. Functional wiring of hypocretin and LC-NE neurons: implications for arousalFront Behav Neurosci. 2013 May 20;7:43.

 

2012

Schöne, C., Cao, Z.F.H., Apergis-Schoute, J., Adamantidis, A., Sakurai, T., and Burdakov, D. Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situJ. Neurosci.32, 12437–12443. (2012).

Sherwood, A., Wosiski-Kuhn, M., Nguyen, T., Holland, P.C., Lakaye, B., Adamantidis, A., and Johnson, A.W. The role of melanin-concentrating hormone in conditioned reward learningEur. J. Neurosci.36, 3126–3133. (2012).

de Lecea, L., Carter, M.E., and Adamantidis, A. Shining Light on Wakefulness and ArousalBiol.

 

older publications

Adamantidis, A.R., Tsai, H.-C., Boutrel, B., Zhang, F., Stuber, G.D., Budygin, E.A., Touriño, C., Bonci, A., Deisseroth, K., and de Lecea, L. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behaviorJ. Neurosci. 31, 10829–10835. (2011).

Karnani, M.M., Apergis-Schoute, J., Adamantidis, A., Jensen, L.T., de Lecea, L., Fugger, L., and Burdakov, D. Activation of central orexin/hypocretin neurons by dietary amino acidsNeuron72, 616–629. (2011).

Adamantidis, A. & de Lecea, L. Optogenetic Probing of Hypocretin Regulation of Wakefulness. In Narcolepsy. Baumann, C.R., Bassetti, C.L., and Scammell, T.E. Springer Eds. (2011).

 Adamantidis, A.R., Zhang, F., de Lecea, L. and Deisseroth, K.D. Optogenetics: Opsins and Optical Interfaces in Neuroscience in “Imaging in Neuroscience: A Laboratory Manual”, Edited By Fritjof Helmchen, Arthur Konnerth,

Zhang, F., Tsai,H.C., Airan, R.D., Stuber, G.D., Adamantidis, A.R., de Lecea, L., Bonci, A. and Deisseroth, K.D.Optogenetics in Freely Moving Mammals: Dopamine and Reward in “Imaging in Neuroscience: A Laboratory Manual”, Edited By Fritjof Helmchen, Arthur Konnerth, Series Editor, Rafael Yuste. Cold Spring Harbor Laboratory Press. (2011)Series Editor, Rafael Yuste. Cold Spring Harbor Laboratory Press. (2011)

Zhang, F., Cong, L., Stuber, G.D., Adamantidis, A., and Deisseroth, K. (2011). Analysis of Neuronal Circuits with Optogenetics. Springer, Humana Press, pp. 207–223.

Zhang F.*, Gradinaru V.*, Adamantidis A.R.*, Durand R., Airan R.D., de Lecea L., Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structuresNat Protoc. 5(3):439-56. (2010).

Carter, M.E., Yizhar, O., Chikahisa, S., Nguyen, H., Adamantidis, A., Nishino, S., Deisseroth, K., and de Lecea, L. Tuning arousal with optogenetic modulation of locus coeruleus neuronsNat. Neurosci.13, 1526–1533. (2010).

Pachoud, B. *, Adamantidis, A. *, Ravassard, P., Luppi, P.-H., Grisar, T., Lakaye, B., and Salin, P.-A. Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1J. Neurophysiol. (London) 104, 1417–1425. (2010).

Adamantidis, A., Carter, M.C., and de Lecea, L. Optogenetic deconstruction of sleep-wake circuitry in the brainFront Mol Neurosci 2, 31. (2010).

Carter, M.E., Adamantidis, A., Ohtsu, H., Deisseroth, K., and de Lecea, L. Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitionsJ. Neurosci.  29, 10939–10949. (2009).

Tsai, H.-C. *, Zhang, F. *, Adamantidis, A., Stuber, G.D., Bonci, A., de Lecea, L., and Deisseroth, K. Phasic firing in dopaminergic neurons is sufficient for behavioral conditioningScience324, 1080–1084. (2009).

 Adamantidis, A., and de Lecea, L. A role for Melanin-Concentrating Hormone in learning and memoryPeptides 30, 2066–2070. (2009a).

 Adamantidis, A., and de Lecea, L. The hypocretins as sensors for metabolism and arousalJ. Physiol. (Lond.) 587, 33–40. (2009b).

Adamantidis A., de Lecea L. Sleep and metabolism: shared circuits, new connectionsTrends Endocrinol Metab. 19(10):362-70.(2008)

Adamantidis A., Salvert D., Goutagny R., Lakaye B., Gervasoni D., Grisar T., Luppi P.H., Fort P. Sleep architecture of the melanin-concentrating hormone receptor 1-knockout miceEur. J. Neurosci. 27(7):1793-800 (2008)

Adamantidis, A.R. *, Zhang, F., * Aravanis, A.M., Deisseroth, K., and de Lecea, L. Neural substrates of awakening probed with optogenetic control of hypocretin neuronsNature 450, 420–424. (2007).

Adamantidis, A. *, Thomas, E. *, Foidart, A., Tyhon, A., Coumans, B., Minet, A., Tirelli, E., Seutin, V., Grisar, T., and Lakaye, B. Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor functionEur. J. Neurosci. 21, 2837–2844. (2005).